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Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
《医学前沿(英文)》 2018年 第12卷 第6期 页码 667-677 doi: 10.1007/s11684-017-0583-y
关键词: platelet-mimicking delivery systems tumor-associated platelets cancer therapy EPR effect
《医学前沿(英文)》 2023年 第17卷 第4期 页码 699-713 doi: 10.1007/s11684-022-0972-8
关键词: anti-CD19 chimeric antigen receptor T immunotherapy diffuse large B cell lymphoma tumor microenvironment tumor-associated macrophage metabolism
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a
《医学前沿(英文)》 2022年 第16卷 第3期 页码 322-338 doi: 10.1007/s11684-021-0901-2
关键词: cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation O-glycans adoptive cell therapy
null
《医学前沿(英文)》 2016年 第10卷 第1期 页码 33-40 doi: 10.1007/s11684-016-0431-5
Breast cancer is the most common malignant tumor in women, and the incidence of this disease has increased in recent years because of changes in diet, living environment, gestational age, and other unknown factors. Previous studies focused on cancer cells, but an increasing number of recent studies have analyzed the contribution of cancer microenvironment to the initiation and progression of breast cancer. Cancer-associated fibroblasts (CAFs), the most abundant cells in tumor stroma, secrete various active biomolecules, including extracellular matrix components, growth factors, cytokines, proteases, and hormones. CAFs not only facilitate the initiation, growth, angiogenesis, invasion, and metastasis of cancer but also serve as biomarkers in the clinical diagnosis, therapy, and prognosis of breast cancer. In this article, we reviewed the literature and summarized the research findings on CAFs in breast cancer.
关键词: cancer-associated fibroblast breast cancer progression prognosis
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
《医学前沿(英文)》 2009年 第3卷 第2期 页码 236-239 doi: 10.1007/s11684-009-0040-7
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
《医学前沿(英文)》 2010年 第4卷 第2期 页码 220-224 doi: 10.1007/s11684-010-0025-6
关键词: arthritis rheumatoid molonuclear cells tumor necrosis factor gene polymorphisms triptolid
Plasma-enabled healing of graphene nano-platelets layer
Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar
《化学科学与工程前沿(英文)》 2019年 第13卷 第2期 页码 350-359 doi: 10.1007/s11705-018-1787-7
关键词: graphene platelet networks anodic arc discharge plasma healing scanning electron microscopy Raman spectroscopy
Heterogeneity of the tumor immune microenvironment and clinical interventions
《医学前沿(英文)》 2023年 第17卷 第4期 页码 617-648 doi: 10.1007/s11684-023-1015-9
Proteins moonlighting in tumor metabolism and epigenetics
Lei Lv, Qunying Lei
《医学前沿(英文)》 2021年 第15卷 第3期 页码 383-403 doi: 10.1007/s11684-020-0818-1
Complex interplay between tumor microenvironment and cancer therapy
null
《医学前沿(英文)》 2018年 第12卷 第4期 页码 426-439 doi: 10.1007/s11684-018-0663-7
Tumor microenvironment (TME) is comprised of cellular and non-cellular components that exist within and around the tumor mass. The TME is highly dynamic and its importance in different stages of cancer progression has been well recognized. A growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses. TME is significantly remodeled upon cancer therapies, and such change either enhances the responses or induces drug resistance. Given the importance of TME in tumor progression and therapy resistance, strategies that remodel TME to improve therapeutic responses are under developing. In this review, we provide an overview of the essential components in TME and the remodeling of TME in response to anti-cancer treatments. We also summarize the strategies that aim to enhance therapeutic efficacy by modulating TME.
关键词: tumor microenvironment therapy response treatment resistance
Crk-associated substrate, vascular smooth muscle and hypertension
TANG Dale
《医学前沿(英文)》 2008年 第2卷 第4期 页码 323-331 doi: 10.1007/s11684-008-0062-6
关键词: Contraction stimulation phosphatase-proline molecular structure discovered hypertension
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 67-78 doi: 10.1007/s11684-012-0176-8
Antitumor angiogenic therapy has been shown promising in the treatment of several advanced cancers since the approval of the first antiangiogenic drug Avastin in 2004. Although the current antiangiogenic drugs reduce the density of tumor blood vessels and result in tumor shrinkage at the early stage of treatment, recent studies have shown that antiangiogenic therapy has transient and insufficient efficacy, resulting in tumor recurrence in patients after several months of treatment. Blockage of blood and oxygen supplies creates a hypoxic and acidic microenvironment in the tumor tissues, which fosters tumor cells to become more aggressive and metastatic. In 2001, Jain proposed tumor vascular normalization as an alternative approach to treating cancers based on the pioneering work on tumor blood vessels by several other researchers. At present, normalizing the disorganized tumor vasculature, rather than disrupting or blocking them, has emerged as a new option for anticancer therapy. Preclinical and clinical data have shown that tumor vascular normalization using monoclonal antibodies, proteins, peptides, small molecules, and pericytes resulted in decreased tumor size and reduced metastasis. However, current tumor vascular normalizing drugs display moderate anticancer efficacy. Accumulated data have shown that a variety of vasculogenic/angiogenic tumor cells and genes play important roles in tumor neovascularization, growth, and metastasis. Therefore, multiple-targeting of vasculogenic tumor cells and genes may improve the efficacy of tumor vascular normalization. To this end, the combination of antiangiogenic drugs with tumor vascular normalizing therapeutics, as well as the integration of Western medicine with traditional Chinese medicine, may provide a good opportunity for discovering novel tumor vascular normalizing drugs for an effective anticancer therapy.
关键词: angiogenesis vasculogenesis neovascularization tumor vasculature normalization traditional Chinese medicine
《医学前沿(英文)》 2022年 第16卷 第3期 页码 459-466 doi: 10.1007/s11684-021-0841-x
关键词: Fanconi anemia aplastic anemia hematologic malignancy germline predisposition
Natural killer cell lines in tumor immunotherapy
null
《医学前沿(英文)》 2012年 第6卷 第1期 页码 56-66 doi: 10.1007/s11684-012-0177-7
Natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells. Current NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potential approaches, including activating autologous NK cells, expanding allogeneic NK cells, usage of stable allogeneic NK cell lines and genetically modifying fresh NK cells or NK cell lines. The stable allogeneic NK cell line approach is more practical for quality-control and large-scale production. Additionally, genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumor antigen receptors could improve their specificity and cytotoxicity. In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines currently undergoing preclinical and clinical trials of several kinds of tumors are reviewed.
关键词: natural killer cell natural killer cell line tumor immunotherapy genetic modification
Kai Shi, Matthew Haynes, Leaf Huang
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 676-684 doi: 10.1007/s11705-017-1640-4
关键词: vaccine nanoparticle tumor immunotherapy microenvironment
标题 作者 时间 类型 操作
Platelet membrane-based and tumor-associated platelet- targeted drug delivery systems for cancer therapy
Yinlong Zhang, Guangna Liu, Jingyan Wei, Guangjun Nie
期刊论文
Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma
期刊论文
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a
期刊论文
Breast cancer-associated fibroblasts: their roles in tumor initiation, progression and clinical applications
null
期刊论文
Expression of protease-activated receptors on platelets in healthy individuals
Rui ZHU, Lin SHEN
期刊论文
Inhibition of TNF-alpha secretion from peripheral blood monocular cells by triptolid is associated with
Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,
期刊论文
Plasma-enabled healing of graphene nano-platelets layer
Xiuqi Fang, Carles Corbella, Denis B. Zolotukhin, Michael Keidar
期刊论文
Progress in tumor vascular normalization for anticancer therapy: challenges and perspectives
null
期刊论文
Fanconi anemia gene-associated germline predisposition in aplastic anemia and hematologic malignancies
期刊论文